| Gene Information | |
|---|---|
| Gene Name | P4HA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 535 |
| Protein Names | Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2) |
| Target Name | prolyl 4-hydroxylase subunit alpha-2 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000072682 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15460 |
| Gene Card | P4HA2 |
| Uniprot ID | O15460 |
| Pfam | PF13640; PF08336 |
| In ASD | no |
| Allosteric Prediction | no (-0.204493224) |
| Ortholog in Animals | Alpaca_ P4HA2 ( ortholog_one2one ) Dog_ P4HA2 ( ortholog_one2one ) GuineaPig_ P4HA2 ( ortholog_one2one ) Macaque_ P4HA2 ( ortholog_one2one ) Mouse_ P4ha2 ( ortholog_one2one ) Pig_ P4HA2 ( ortholog_one2one ) Rat_ P4ha2 ( ortholog_one2one ) Rabbit_ P4HA2 ( ortholog_one2one ) |
| Ohnologs | P4HA1 |
| Paralogs | P4HA3, P4HTM, P4HA1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the heart, placenta, lung and pancreas. {ECO:0000269|PubMed:9211872}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6EVL (X-ray 1.87A ) 6EVM (X-ray 2.00A ) 6EVN (X-ray 1.48A ) 6EVO (X-ray 1.55A ) 6EVP (X-ray 1.68A ) |
| DBSNP | rs764211125 rs771208496 rs758872875 |
| Subcellular location [CC] | Endoplasmic reticulum lumen. |
| Mouse PG classification | NA |
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