| Gene Information | |
|---|---|
| Gene Name | PIAS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 628 |
| Protein Names | E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000131788 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6X2 |
| Gene Card | PIAS3 |
| Uniprot ID | Q9Y6X2 |
| Pfam | PF14324; PF02891 |
| In ASD | no |
| Allosteric Prediction | yes (0.223852136) |
| Ortholog in Animals | Alpaca_ PIAS3 ( ortholog_one2one ) Dog_ PIAS3 ( ortholog_one2one ) GuineaPig_ PIAS3 ( ortholog_one2one ) Mouse_ Pias3 ( ortholog_one2one ) Pig_ PIAS3 ( ortholog_one2one ) Rat_ Pias3 ( ortholog_one2one ) Rabbit_ PIAS3 ( ortholog_one2one ) |
| Ohnologs | PIAS1, PIAS2, PIAS4 |
| Paralogs | PIAS1, PIAS2, PIAS4, ZMIZ2, ZMIZ1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9388184}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001546(Rat);0.035294(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4MVT (X-ray 2.30A ) |
| DBSNP | rs17354559 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000250|UniProtKB:O54714}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}. |
| Mouse PG classification | NA |
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