| Gene Information | |
|---|---|
| Gene Name | MPDZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 2070 |
| Protein Names | Multiple PDZ domain protein (Multi-PDZ domain protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000107186 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O75970 |
| Gene Card | MPDZ |
| Uniprot ID | O75970 |
| Pfam | PF09045; PF16667; PF00595 |
| In ASD | yes |
| Allosteric Prediction | yes (0.646361421) |
| Ortholog in Animals | Alpaca_ MPDZ ( ortholog_one2one ) Dog_ MPDZ ( ortholog_one2one ) GuineaPig_ MPDZ ( ortholog_one2one ) Macaque_ MPDZ ( ortholog_one2one ) Mouse_ Mpdz ( ortholog_one2one ) Pig_ MPDZ ( ortholog_one2one ) Rat_ Mpdz ( ortholog_one2one ) Rabbit_ MPDZ ( ortholog_one2one ) |
| Ohnologs | PATJ |
| Paralogs | FRMPD2, LNX1, LNX2, STXBP4, PATJ |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9537516}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2FCF (X-ray 1.76A ) 2FNE (X-ray 1.83A ) 2IWN (X-ray 1.35A ) 2IWO (X-ray 1.70A ) 2IWP (X-ray 2.15A ) 2IWQ (X-ray 1.80A ) 2O2T (X-ray 2.70A ) 2OPG (X-ray 1.50A ) 2QG1 (X-ray 1.40A ) |
| DBSNP | rs17273542 rs372127610 rs3739757 rs4741289 rs4740548 rs922703465 rs376078512 rs16930134 rs2274648 rs1554644827 |
| Subcellular location [CC] | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Synapse. Synapse, synaptosome. Note=Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells (By similarity). Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. {ECO:0000250, ECO:0000250|UniProtKB:O55164}. |
| Mouse PG classification | LPG |
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