| Gene Information | |
|---|---|
| Gene Name | ARHGEF26 |
| Organism | Homo sapiens (Human) |
| Gene Length | 871 |
| Protein Names | Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000114790 ) 3 ( ENSG00000277101 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96DR7 |
| Gene Card | ARHGEF26 |
| Uniprot ID | Q96DR7 |
| Pfam | PF00621; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.68433156) |
| Ortholog in Animals | Alpaca_ ARHGEF26 ( ortholog_one2one ) Dog_ ARHGEF26 ( ortholog_one2one ) GuineaPig_ ARHGEF26 ( ortholog_one2one ) Macaque_ ARHGEF26 ( ortholog_one2one ) Mouse_ Arhgef26 ( ortholog_one2one ) Pig_ ARHGEF26 ( ortholog_one2one ) Rat_ Arhgef26 ( ortholog_one2one ) Rabbit_ ARHGEF26 ( ortholog_one2one ) |
| Ohnologs | ARHGEF5, ARHGEF15, ARHGEF34P, NGEF, ARHGEF16, ARHGEF19 |
| Paralogs | ARHGEF16, ARHGEF19, ARHGEF35, ARHGEF15, NGEF, ARHGEF5 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. {ECO:0000269|PubMed:12697679, ECO:0000269|PubMed:15133129}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6MYE (X-ray 1.10A ) |
| DBSNP | rs12493885 rs12497267 rs13096373 |
| Subcellular location [CC] | Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}. |
| Mouse PG classification | NA |
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