| Gene Information | |
|---|---|
| Gene Name | CSF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 144 |
| Protein Names | Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) |
| Target Name | granulocyte-macrophage colony-stimulating factor |
| Target Type | Successful target |
| Gene Age | 424 ( ENSG00000164400 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P04141 |
| Gene Card | CSF2 |
| Uniprot ID | P04141 |
| Pfam | PF01109 |
| In ASD | no |
| Allosteric Prediction | yes (0.297333921) |
| Ortholog in Animals | Alpaca_ CSF2 ( ortholog_one2one ) Dog_ CSF2 ( ortholog_one2one ) GuineaPig_ CSF2 ( ortholog_one2one ) Macaque_ CSF2 ( ortholog_one2one ) Mouse_ Csf2 ( ortholog_one2one ) Pig_ CSF2 ( ortholog_one2one ) Rat_ Csf2 ( ortholog_one2one ) Rabbit_ CSF2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.004323(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CSG (X-ray 2.70A ) 2GMF (X-ray 2.40A ) 4NKQ (X-ray 3.30A ) 4RS1 (X-ray 2.68A ) 5C7X (X-ray 2.95A ) 5D70 (X-ray 2.06A ) 5D71 (X-ray 2.25A ) 5D72 (X-ray 2.60A ) 6BFQ (X-ray 2.60A ) 6BFS (X-ray 2.00A ) |
| DBSNP | rs2069640 rs25882 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:1737041, ECO:0000269|PubMed:3925454}. |
| Mouse PG classification | NA |
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