| Gene Information | |
|---|---|
| Gene Name | GABARAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 117 |
| Protein Names | Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000170296 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95166 |
| Gene Card | GABARAP |
| Uniprot ID | O95166 |
| Pfam | PF02991 |
| In ASD | no |
| Allosteric Prediction | yes (0.096409422) |
| Ortholog in Animals | Alpaca_ GABARAP ( ortholog_one2one ) Dog_ GABARAP ( ortholog_one2one ) Macaque_ GABARAP ( ortholog_one2one ) Mouse_ Gabarap ( ortholog_one2one ) Pig_ GABARAP ( ortholog_one2one ) Rabbit_ GABARAP ( ortholog_one2one ) |
| Ohnologs | GABARAPL1 |
| Paralogs | MAP1LC3C, GABARAPL1, MAP1LC3A, GABARAPL2, MAP1LC3B2, MAP1LC3B |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11146101, ECO:0000269|PubMed:9892355}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025532(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1GNU (X-ray 1.75A ) 1KLV (NMR - ) 1KM7 (NMR - ) 1KOT (NMR - ) 3D32 (X-ray 1.30A ) 3DOW (X-ray 2.30A ) 3WIM (X-ray 2.60A ) 4XC2 (X-ray 1.90A ) 5DPS (X-ray 2.00A ) 6HB9 (X-ray 1.30A ) 6HOG (X-ray 1.26A ) 6HOH (X-ray 2.25A ) 6HOJ (X-ray 1.51A ) 6HOK (X-ray 1.61A ) 6HYL (X-ray 1.56A ) 6HYM (X-ray 1.86A ) 6HYN (X-ray 1.14A ) 6HYO (X-ray 1.07A ) 6YOP (X-ray 1.10A ) 7AA8 (X-ray 1.25A ) 7BRQ (X-ray 1.40A ) 7BRT (X-ray 2.00A ) 7BRU (X-ray 2.15A ) 7BV4 (X-ray 2.00A ) 7EA7 (X-ray 2.69A ) 7LSW (X-ray 3.05A ) 7LT6 (X-ray 1.80A ) 7VEC (X-ray 3.00A ) 7VED (X-ray 2.02A ) 7ZKR (X-ray 1.10A ) 7ZL7 (X-ray 1.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12507496, ECO:0000269|PubMed:15169837, ECO:0000269|PubMed:17580304, ECO:0000269|PubMed:19056683}. Endomembrane system {ECO:0000250|UniProtKB:P60517}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60517}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P60517}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P60517}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:P60517, ECO:0000250|UniProtKB:Q9DCD6}. |
| Mouse PG classification | NA |
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