| Gene Information | |
|---|---|
| Gene Name | MOP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 826 |
| Protein Names | Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q16665 |
| Gene Card | HIF1A |
| Uniprot ID | Q16665 |
| Pfam | PF11413; PF08778; PF00989; PF08447 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland. {ECO:0000269|PubMed:22009797}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.346036(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1H2K (X-ray 2.15A ) 1H2L (X-ray 2.25A ) 1H2M (X-ray 2.50A ) 1L3E (NMR - ) 1L8C (NMR - ) 1LM8 (X-ray 1.85A ) 1LQB (X-ray 2.00A ) 2ILM (X-ray 2.30A ) 3HQR (X-ray 2.00A ) 3HQU (X-ray 2.30A ) 4AJY (X-ray 1.73A ) 4H6J (X-ray 1.52A ) 5JWP (X-ray 2.10A ) 5L9B (X-ray 1.95A ) 5L9V (X-ray 1.83A ) 5LA9 (X-ray 2.81A ) 5LAS (X-ray 2.10A ) 6GFX (X-ray 1.83A ) 6GMR (X-ray 1.75A ) 6YW3 (X-ray 2.28A ) 7LVS (X-ray 2.02A ) 7QGS (X-ray 2.00A ) |
| DBSNP | rs11549465 rs11549467 rs1802821 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9822602}. Nucleus {ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:9822602}. Nucleus speckle {ECO:0000250|UniProtKB:Q61221}. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia (PubMed:9822602). {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:9822602}. |
| Mouse PG classification | NA |
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