| Gene Information | |
|---|---|
| Gene Name | MOCS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 188 |
| Protein Names | Molybdopterin synthase catalytic subunit (EC 2.8.1.12) (MOCO1-B) (Molybdenum cofactor synthesis protein 2 large subunit) (Molybdenum cofactor synthesis protein 2B) (MOCS2B) (Molybdopterin-synthase large subunit) (MPT synthase large subunit) |
| Target Name | molybdopterin synthase catalytic subunit |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000164172 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O96007 |
| Gene Card | MOCS2 |
| Uniprot ID | O96007 |
| Pfam | PF02391 |
| In ASD | no |
| Allosteric Prediction | no (-1.479755285) |
| Ortholog in Animals | Alpaca_ MOCS2 ( ortholog_one2one ) GuineaPig_ MOCS2 ( ortholog_one2one ) Macaque_ MOCS2 ( ortholog_one2one ) Mouse_ Mocs2 ( ortholog_one2one ) Pig_ MOCS2 ( ortholog_one2one ) Rat_ Mocs2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MBIP, NMRK2, NMRK1 |
| Tissue | NA |
| Tissue Specificity | Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10053003}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4AP8 (X-ray 2.78A ) 5MPO (X-ray 2.43A ) |
| DBSNP | rs2233213 rs2233215 rs2233218 rs121908605 rs2233221 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03052, ECO:0000269|PubMed:15073332}. |
| Mouse PG classification | NA |
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