| Gene Information | |
|---|---|
| Gene Name | PLEKHG5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1006 |
| Protein Names | Pleckstrin homology domain-containing family G member 5 (PH domain-containing family G member 5) (Guanine nucleotide exchange factor 720) (GEF720) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171680 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94827 |
| Gene Card | PLEKHG5 |
| Uniprot ID | O94827 |
| Pfam | PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.186203201) |
| Ortholog in Animals | Alpaca_ PLEKHG5 ( ortholog_one2one ) Dog_ PLEKHG5 ( ortholog_one2one ) GuineaPig_ PLEKHG5 ( ortholog_one2one ) Macaque_ PLEKHG5 ( ortholog_one2one ) Mouse_ Plekhg5 ( ortholog_one2one ) Pig_ PLEKHG5 ( ortholog_one2one ) Rat_ Plekhg5 ( ortholog_one2one ) Rabbit_ PLEKHG5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PLEKHG7 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in the peripheral nervous system and brain. Highest expression is observed in heart, lung, kidney, testis and moderate expression is present in spleen, pancreas, skeletal muscle, ovary and liver. Weakly expressed in glioblastoma (GBM) cell lines. {ECO:0000269|PubMed:11704860, ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:9872452}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs63750315 rs397515456 rs202191898 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q66T02}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q66T02}. Cell membrane {ECO:0000250|UniProtKB:Q66T02}. Cell junction {ECO:0000250|UniProtKB:Q66T02}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q66T02}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane. Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells. {ECO:0000250|UniProtKB:Q66T02}. |
| Mouse PG classification | LPG |
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