| Gene Information | |
|---|---|
| Gene Name | SLC38A3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Sodium-coupled neutral amino acid transporter 3 (N-system amino acid transporter 1) (Na(+)-coupled neutral amino acid transporter 3) (Solute carrier family 38 member 3) (System N amino acid transporter 1) |
| Target Name | sodium-coupled neutral amino acid transporters |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000188338 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99624 |
| Gene Card | SLC38A3 |
| Uniprot ID | Q99624 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | yes (0.396458851) |
| Ortholog in Animals | Alpaca_ SLC38A3 ( ortholog_one2one ) Dog_ SLC38A3 ( ortholog_one2one ) GuineaPig_ SLC38A3 ( ortholog_one2one ) Macaque_ SLC38A3 ( ortholog_one2one ) Mouse_ Slc38a3 ( ortholog_one2one ) Pig_ SLC38A3 ( ortholog_one2one ) Rat_ Slc38a3 ( ortholog_one2one ) Rabbit_ SLC38A3 ( ortholog_one2one ) |
| Ohnologs | SLC38A5, SLC38A1, SLC38A2, SLC38A4, SLC38A8 |
| Paralogs | SLC36A1, SLC36A4, SLC38A10, SLC38A9, SLC36A3, SLC38A7, SLC38A8, SLC38A2, SLC36A2, SLC38A4, SLC38A11, SLC38A6, SLC32A1, SLC38A1, SLC38A5 |
| Tissue | liver, artery, pineal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q9DCP2}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9DCP2}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9}. |
| Mouse PG classification | NA |
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