| Gene Information | |
|---|---|
| Gene Name | MNB |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13627 |
| Gene Card | DYRK1A |
| Uniprot ID | Q13627 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney. {ECO:0000269|PubMed:10329007, ECO:0000269|PubMed:8769099, ECO:0000269|PubMed:8872470, ECO:0000269|PubMed:8975710}. |
| Pharmacological Animal Models | 0.006414(Chimpanzee);0.006790(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2VX3 (X-ray 2.40A ) 2WO6 (X-ray 2.50A ) 3ANQ (X-ray 2.60A ) 3ANR (X-ray 2.60A ) 4AZE (X-ray 3.15A ) 4MQ1 (X-ray 2.35A ) 4MQ2 (X-ray 2.80A ) 4NCT (X-ray 2.60A ) 4YLJ (X-ray 2.58A ) 4YLK (X-ray 1.40A ) 4YLL (X-ray 1.40A ) 4YU2 (X-ray 2.90A ) 5A3X (X-ray 2.26A ) 5A4E (X-ray 2.68A ) 5A4L (X-ray 2.73A ) 5A4Q (X-ray 2.37A ) 5A4T (X-ray 2.15A ) 5A54 (X-ray 2.63A ) 5AIK (X-ray 2.70A ) 6A1F (X-ray 1.50A ) 6A1G (X-ray 2.15A ) 6EIF (X-ray 2.22A ) 6EIJ (X-ray 2.42A ) 6EIL (X-ray 2.46A ) 6EIP (X-ray 2.56A ) 6EIQ (X-ray 2.30A ) 6EIR (X-ray 2.40A ) 6EIS (X-ray 2.36A ) 6EIV (X-ray 2.68A ) 6EJ4 (X-ray 2.88A ) 6LN1 (X-ray 2.70A ) 6QU2 (X-ray 2.90A ) 6S11 (X-ray 2.44A ) 6S14 (X-ray 1.05A ) 6S17 (X-ray 1.10A ) 6S1B (X-ray 1.30A ) 6S1H (X-ray 1.05A ) 6S1I (X-ray 2.38A ) 6S1J (X-ray 1.41A ) 6T6A (X-ray 2.80A ) 6UIP (X-ray 3.70A ) 6UWY (X-ray 2.95A ) 6YF8 (X-ray 3.20A ) 7A4O (X-ray 1.90A ) 7A4R (X-ray 1.80A ) 7A4S (X-ray 3.10A ) 7A4W (X-ray 2.70A ) 7A4Z (X-ray 1.90A ) 7A51 (X-ray 1.90A ) 7A52 (X-ray 2.10A ) 7A53 (X-ray 2.20A ) 7A55 (X-ray 2.20A ) 7A5B (X-ray 2.60A ) 7A5D (X-ray 1.80A ) 7A5L (X-ray 2.10A ) 7A5N (X-ray 2.30A ) 7AJ2 (X-ray 2.10A ) 7AJ4 (X-ray 2.00A ) 7AJ5 (X-ray 2.00A ) 7AJ7 (X-ray 2.90A ) 7AJ8 (X-ray 2.00A ) 7AJA (X-ray 2.20A ) 7AJM (X-ray 2.40A ) 7AJS (X-ray 2.15A ) 7AJV (X-ray 2.10A ) 7AJW (X-ray 2.80A ) 7AJY (X-ray 2.20A ) 7AK2 (X-ray 2.10A ) 7AKA (X-ray 1.90A ) 7AKB (X-ray 2.80A ) 7AKE (X-ray 2.30A ) 7AKL (X-ray 2.00A ) 7FHS (X-ray 2.42A ) 7FHT (X-ray 2.68A ) 7O7K (X-ray 1.82A ) 7OY6 (X-ray 2.38A ) |
| DBSNP | rs55720916 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20167603, ECO:0000269|PubMed:23415227, ECO:0000269|PubMed:25620562}. Nucleus speckle {ECO:0000250|UniProtKB:Q61214}. |
| Mouse PG classification | NA |
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