| Gene Information | |
|---|---|
| Gene Name | ING1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 422 |
| Protein Names | Inhibitor of growth protein 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000153487 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UK53 |
| Gene Card | ING1 |
| Uniprot ID | Q9UK53 |
| Pfam | PF12998 |
| In ASD | no |
| Allosteric Prediction | yes (0.133325296) |
| Ortholog in Animals | Alpaca_ ING1 ( ortholog_one2one ) Dog_ ING1 ( ortholog_one2one ) GuineaPig_ ING1 ( ortholog_one2one ) Macaque_ ING1 ( ortholog_one2one ) Mouse_ Ing1 ( ortholog_one2one ) Pig_ ING1 ( ortholog_one2one ) Rat_ Ing1 ( ortholog_one2one ) Rabbit_ ING1 ( ortholog_one2one ) |
| Ohnologs | ING5 |
| Paralogs | ING3, ING4, ING5, ING2 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines. {ECO:0000269|PubMed:10626813}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2QIC (X-ray 2.10A ) |
| DBSNP | rs7338333 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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