| Gene Information | |
|---|---|
| Gene Name | GPRC5B |
| Organism | Homo sapiens (Human) |
| Gene Length | 403 |
| Protein Names | G-protein coupled receptor family C group 5 member B (A-69G12.1) (Retinoic acid-induced gene 2 protein) (RAIG-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000167191 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NZH0 |
| Gene Card | GPRC5B |
| Uniprot ID | Q9NZH0 |
| Pfam | PF00003 |
| In ASD | yes |
| Allosteric Prediction | yes (0.21997809) |
| Ortholog in Animals | Alpaca_ GPRC5B ( ortholog_one2one ) Dog_ GPRC5B ( ortholog_one2one ) GuineaPig_ GPRC5B ( ortholog_one2one ) Macaque_ GPRC5B ( ortholog_one2one ) Mouse_ Gprc5b ( ortholog_one2one ) Pig_ GPRC5B ( ortholog_one2one ) Rat_ Gprc5b ( ortholog_one2one ) Rabbit_ GPRC5B ( ortholog_one2one ) |
| Ohnologs | GPRC5C |
| Paralogs | GPRC5C, GPRC5D, GPRC5A |
| Tissue | NA |
| Tissue Specificity | Expression is high in kidney, pancreas, and testis, medium in brain, heart, prostate, small intestine, and spleen, low in liver, placenta, skeletal muscle, colon, ovary, and thymus, and not detectable in lung and peripheral leukocyte. According to PubMed:10945465, highly expressed in most brain areas examined, with the highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus, and spinal cord as well as in dorsal root ganglia (DRG). In the periphery, expression levels are relatively low, compared to the CNS, with the strongest expression detected in pancreas, testis, uterus, and stomach. {ECO:0000269|PubMed:10783259, ECO:0000269|PubMed:10945465}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10945465}; Multi-pass membrane protein {ECO:0000269|PubMed:10945465}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10945465}; Multi-pass membrane protein {ECO:0000269|PubMed:10945465}. Note=Localized in the plasma membrane and perinuclear vesicles. |
| Mouse PG classification | NA |
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