| Gene Information | |
|---|---|
| Gene Name | VSIG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000101842 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q86XK7 |
| Gene Card | VSIG1 |
| Uniprot ID | Q86XK7 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-1.059720858) |
| Ortholog in Animals | Alpaca_ VSIG1 ( ortholog_one2one ) Dog_ VSIG1 ( ortholog_one2one ) GuineaPig_ VSIG1 ( ortholog_one2one ) Macaque_ VSIG1 ( ortholog_one2one ) Mouse_ Vsig1 ( ortholog_one2one ) Pig_ VSIG1 ( ortholog_one2one ) Rat_ Vsig1 ( ortholog_one2one ) Rabbit_ VSIG1 ( ortholog_one2one ) |
| Ohnologs | GPA33 |
| Paralogs | MXRA8, IGSF11, JAM3, VSIG2, JAM2, ESAM, F11R, MUC15, GPA33, CXADR, VSTM2B, VSIR, VSIG8, CLMP |
| Tissue | stomach, testis |
| Tissue Specificity | Detected only in stomach mucosa and testis, and to a much lesser level in pancreas (at protein level). Detected in gastric cancers (31%), esophageal carcinomas (50%) and ovarian cancers (23%). {ECO:0000269|PubMed:16405301}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17254305 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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