| Gene Information | |
|---|---|
| Gene Name | MMRN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1228 |
| Protein Names | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138722 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13201 |
| Gene Card | MMRN1 |
| Uniprot ID | Q13201 |
| Pfam | PF00386; PF00008; PF07546 |
| In ASD | no |
| Allosteric Prediction | yes (0.16457566) |
| Ortholog in Animals | Alpaca_ MMRN1 ( ortholog_one2one ) Dog_ MMRN1 ( ortholog_one2one ) GuineaPig_ MMRN1 ( ortholog_one2one ) Macaque_ MMRN1 ( ortholog_one2one ) Mouse_ Mmrn1 ( ortholog_one2one ) Pig_ MMRN1 ( ortholog_one2one ) Rat_ Mmrn1 ( ortholog_one2one ) Rabbit_ MMRN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MMRN2, EMILIN3, EMILIN2, EMILIN1 |
| Tissue | NA |
| Tissue Specificity | Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. {ECO:0000269|PubMed:7629143, ECO:0000269|PubMed:8514871}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1442138 rs3756065 rs12646270 rs17855885 |
| Subcellular location [CC] | Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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