| Gene Information | |
|---|---|
| Gene Name | MMP9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 707 |
| Protein Names | Matrix metalloproteinase-9 (MMP-9) (EC 3.4.24.35) (92 kDa gelatinase) (92 kDa type IV collagenase) (Gelatinase B) (GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9] |
| Target Name | matrix metalloproteinase-9 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000100985 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P14780 |
| Gene Card | MMP9 |
| Uniprot ID | P14780 |
| Pfam | PF00040; PF00045; PF00413; PF01471 |
| In ASD | yes |
| Allosteric Prediction | yes (1.612501218) |
| Ortholog in Animals | Alpaca_ MMP9 ( ortholog_one2one ) Dog_ MMP9 ( ortholog_one2one ) GuineaPig_ MMP9 ( ortholog_one2one ) Macaque_ MMP9 ( ortholog_one2one ) Mouse_ Mmp9 ( ortholog_one2one ) Pig_ MMP9 ( ortholog_one2one ) Rat_ Mmp9 ( ortholog_one2one ) Rabbit_ MMP9 ( ortholog_one2one ) |
| Ohnologs | MMP2 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | bone.marrow, spleen, whole.blood |
| Tissue Specificity | Detected in neutrophils (at protein level) (PubMed:7683678). Produced by normal alveolar macrophages and granulocytes. {ECO:0000269|PubMed:7683678}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1GKC (X-ray 2.30A ) 1GKD (X-ray 2.10A ) 1ITV (X-ray 1.95A ) 1L6J (X-ray 2.50A ) 2OVX (X-ray 2.00A ) 2OVZ (X-ray 2.00A ) 2OW0 (X-ray 2.00A ) 2OW1 (X-ray 2.20A ) 2OW2 (X-ray 2.90A ) 4H1Q (X-ray 1.59A ) 4H2E (X-ray 2.90A ) 4H3X (X-ray 1.76A ) 4H82 (X-ray 1.90A ) 4HMA (X-ray 1.94A ) 4JIJ (X-ray 1.70A ) 4JQG (X-ray 1.85A ) 4WZV (X-ray 1.65A ) 4XCT (X-ray 1.30A ) 5CUH (X-ray 1.83A ) 5I12 (X-ray 1.59A ) 5TH6 (X-ray 1.70A ) 5TH9 (X-ray 3.00A ) 5UE3 (X-ray 1.60A ) 5UE4 (X-ray 1.80A ) 6ESM (X-ray 1.10A ) |
| DBSNP | rs1805088 rs41427445 rs1805089 rs3918252 rs28763886 rs17576 rs35691798 rs2250889 rs17577 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:2551898}. |
| Mouse PG classification | HPG |
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