| Gene Information | |
|---|---|
| Gene Name | MMP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 467 |
| Protein Names | Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) |
| Target Name | matrix metalloproteinase-8 |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000118113 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P22894 |
| Gene Card | MMP8 |
| Uniprot ID | P22894 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | yes (0.785180692) |
| Ortholog in Animals | Alpaca_ MMP8 ( ortholog_one2one ) Dog_ MMP8 ( ortholog_one2one ) GuineaPig_ MMP8 ( ortholog_one2one ) Macaque_ MMP8 ( ortholog_one2one ) Mouse_ Mmp8 ( ortholog_one2one ) Pig_ MMP8 ( ortholog_one2one ) Rat_ Mmp8 ( ortholog_one2one ) Rabbit_ MMP8 ( ortholog_one2one ) |
| Ohnologs | MMP25, MMP2, MMP11, MMP15, MMP17, MMP16 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP3, MMP11 |
| Tissue | bone.marrow, left.ventricle, spleen, vagina, whole.blood |
| Tissue Specificity | Neutrophils. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A85 (X-ray 2.00A ) 1A86 (X-ray 2.00A ) 1BZS (X-ray 1.70A ) 1I73 (X-ray 1.40A ) 1I76 (X-ray 1.20A ) 1JAN (X-ray 2.50A ) 1JAO (X-ray 2.40A ) 1JAP (X-ray 1.82A ) 1JAQ (X-ray 2.40A ) 1JH1 (X-ray 2.70A ) 1JJ9 (X-ray 2.00A ) 1KBC (X-ray 1.80A ) 1MMB (X-ray 2.10A ) 1MNC (X-ray 2.10A ) 1ZP5 (X-ray 1.80A ) 1ZS0 (X-ray 1.56A ) 1ZVX (X-ray 1.87A ) 2OY2 (X-ray 1.50A ) 2OY4 (X-ray 1.70A ) 3DNG (X-ray 2.00A ) 3DPE (X-ray 1.60A ) 3DPF (X-ray 2.10A ) 3TT4 (X-ray 1.88A ) 4QKZ (X-ray 1.20A ) 5H8X (X-ray 1.30A ) |
| DBSNP | rs17099450 rs3765620 rs1940475 rs35056226 rs34428739 rs35243553 rs34009635 rs35866072 |
| Subcellular location [CC] | Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules. |
| Mouse PG classification | NA |
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