| Gene Information | |
|---|---|
| Gene Name | PDZD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2839 |
| Protein Names | PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000133401 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | PDZD2 |
| Uniprot ID | O15018 |
| Pfam | PF00595 |
| In ASD | no |
| Allosteric Prediction | no (-1.312126357) |
| Ortholog in Animals | Alpaca_ PDZD2 ( ortholog_one2one ) Dog_ PDZD2 ( ortholog_one2one ) GuineaPig_ PDZD2 ( ortholog_one2one ) Macaque_ PDZD2 ( ortholog_one2one ) Mouse_ Pdzd2 ( ortholog_one2one ) Rat_ Pdzd2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL16 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed (at protein level) in prostate and many prostate tumors. {ECO:0000269|PubMed:11289102}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs57158698 rs3101878 rs157496 rs12520467 rs36097367 rs3101873 rs10066063 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q9QZR8}. Cytoplasm {ECO:0000269|PubMed:11289102}. Endoplasmic reticulum {ECO:0000269|PubMed:11289102}. Note=At cell-cell contacts in lung epithelial cells. {ECO:0000250|UniProtKB:Q9QZR8}.; [Processed PDZ domain-containing protein 2]: Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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