| Gene Information | |
|---|---|
| Gene Name | MMP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 477 |
| Protein Names | Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) |
| Target Name | stromelysin-1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000149968 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P08254 |
| Gene Card | MMP3 |
| Uniprot ID | P08254 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | yes (0.951183273) |
| Ortholog in Animals | Alpaca_ MMP3 ( ortholog_one2one ) Dog_ MMP3 ( ortholog_one2one ) GuineaPig_ MMP3 ( ortholog_one2one ) Macaque_ MMP3 ( ortholog_one2one ) Mouse_ Mmp3 ( ortholog_one2one ) Pig_ MMP3 ( ortholog_one2one ) Rat_ Mmp3 ( ortholog_one2one ) Rabbit_ MMP3 ( ortholog_one2one ) |
| Ohnologs | MMP25, MMP2, MMP11, MMP15, MMP17, MMP16 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP11 |
| Tissue | endometrium, epididymis, minor.salivary.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1B3D (X-ray 2.30A ) 1B8Y (X-ray 2.00A ) 1BIW (X-ray 2.50A ) 1BM6 (NMR - ) 1BQO (X-ray 2.30A ) 1C3I (X-ray 1.83A ) 1C8T (X-ray 2.60A ) 1CAQ (X-ray 1.80A ) 1CIZ (X-ray 1.64A ) 1CQR (X-ray 2.00A ) 1D5J (X-ray 2.60A ) 1D7X (X-ray 2.00A ) 1D8F (X-ray 2.40A ) 1D8M (X-ray 2.44A ) 1G05 (X-ray 2.45A ) 1G49 (X-ray 1.90A ) 1G4K (X-ray 2.00A ) 1HFS (X-ray 1.70A ) 1HY7 (X-ray 1.50A ) 1OO9 (NMR - ) 1QIA (X-ray 2.00A ) 1QIC (X-ray 2.00A ) 1SLM (X-ray 1.90A ) 1SLN (X-ray 2.27A ) 1UEA (X-ray 2.80A ) 1UMS (NMR - ) 1UMT (NMR - ) 1USN (X-ray 1.80A ) 2D1O (X-ray 2.02A ) 2JNP (NMR - ) 2JT5 (NMR - ) 2JT6 (NMR - ) 2SRT (NMR - ) 2USN (X-ray 2.20A ) 3OHL (X-ray 2.36A ) 3OHO (X-ray 2.50A ) 3USN (NMR - ) 4DPE (X-ray 1.96A ) 4G9L (X-ray 1.88A ) 4JA1 (X-ray 1.96A ) 6MAV (X-ray 2.37A ) 6N9D (X-ray 2.67A ) 7S7L (X-ray 2.34A ) 7S7M (X-ray 3.00A ) |
| DBSNP | rs679620 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix. Nucleus {ECO:0000269|PubMed:35940311}. Cytoplasm {ECO:0000269|PubMed:35940311}. |
| Mouse PG classification | NA |
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