| Gene Information | |
|---|---|
| Gene Name | MMP24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 645 |
| Protein Names | Matrix metalloproteinase-24 (MMP-24) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (MTMMP5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MT5MMP) [Cleaved into: Processed matrix metalloproteinase-24] |
| Target Name | matrix metalloproteinase-24 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125966 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5R2 |
| Gene Card | MMP24 |
| Uniprot ID | Q9Y5R2 |
| Pfam | PF11857; PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | no (-0.235879193) |
| Ortholog in Animals | Alpaca_ MMP24 ( ortholog_one2one ) Dog_ MMP24 ( ortholog_one2one ) GuineaPig_ MMP24 ( ortholog_one2one ) Macaque_ MMP24 ( ortholog_one2one ) Mouse_ Mmp24 ( ortholog_one2one ) Pig_ MMP24 ( ortholog_one2one ) Rat_ Mmp24 ( ortholog_one2one ) Rabbit_ MMP24 ( ortholog_one2one ) |
| Ohnologs | MMP11, MMP2, MMP15, MMP16, MMP14 |
| Paralogs | MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas. {ECO:0000269|PubMed:10363975}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs751887 |
| Subcellular location [CC] | [Matrix metalloproteinase-24]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |