| Gene Information | |
|---|---|
| Gene Name | NCAPH |
| Organism | Homo sapiens (Human) |
| Gene Length | 741 |
| Protein Names | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 8 ( ENSG00000121152 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15003 |
| Gene Card | NCAPH |
| Uniprot ID | Q15003 |
| Pfam | PF05786 |
| In ASD | no |
| Allosteric Prediction | no (-0.160651852) |
| Ortholog in Animals | Alpaca_ NCAPH ( ortholog_one2one ) Dog_ NCAPH ( ortholog_one2one ) GuineaPig_ NCAPH ( ortholog_one2one ) Macaque_ NCAPH ( ortholog_one2one ) Mouse_ Ncaph ( ortholog_one2one ) Pig_ NCAPH ( ortholog_one2one ) Rat_ Ncaph ( ortholog_one2one ) Rabbit_ NCAPH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Widely expressed at low level. Expressed in proliferating cells. {ECO:0000269|PubMed:11694586}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.023036(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6IGX (X-ray 3.00A ) |
| DBSNP | rs1553446603 rs2305935 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11694586}. Cytoplasm {ECO:0000269|PubMed:11694586}. Chromosome {ECO:0000269|PubMed:11694586}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
| Mouse PG classification | NA |
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