| Gene Information | |
|---|---|
| Gene Name | MMP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 660 |
| Protein Names | 72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX] |
| Target Name | matrix metalloproteinase-2 |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000087245 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P08253 |
| Gene Card | MMP2 |
| Uniprot ID | P08253 |
| Pfam | PF00040; PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | yes (1.278531999) |
| Ortholog in Animals | Alpaca_ MMP2 ( ortholog_one2one ) Dog_ MMP2 ( ortholog_one2one ) GuineaPig_ MMP2 ( ortholog_one2one ) Macaque_ MMP2 ( ortholog_one2one ) Mouse_ Mmp2 ( ortholog_one2one ) Pig_ MMP2 ( ortholog_one2one ) Rat_ Mmp2 ( ortholog_one2one ) Rabbit_ MMP2 ( ortholog_one2one ) |
| Ohnologs | MMP11, MMP9, MMP24, MMP25, MMP8, MMP20, MMP27, MMP13, MMP3, MMP16, MMP10, MMP1 |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | NA |
| Tissue Specificity | Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. {ECO:0000269|PubMed:11751392}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CK7 (X-ray 2.80A ) 1CXW (NMR - ) 1EAK (X-ray 2.66A ) 1GEN (X-ray 2.15A ) 1GXD (X-ray 3.10A ) 1HOV (NMR - ) 1J7M (NMR - ) 1KS0 (NMR - ) 1QIB (X-ray 2.80A ) 1RTG (X-ray 2.60A ) 3AYU (X-ray 2.00A ) |
| DBSNP | rs121912953 rs759302357 rs121912955 rs17859943 rs764961297 rs16955280 |
| Subcellular location [CC] | [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2834383}. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; [Isoform 2]: Cytoplasm. Mitochondrion. |
| Mouse PG classification | NA |
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