Gene Information
Gene NameMMP14
OrganismHomo sapiens (Human)
Gene Length582
Protein NamesMatrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Target Namematrix metalloproteinase-14
Target TypeClinical trial target
Gene Age680 ( ENSG00000157227 )
Evolutionary StageEumetazoa
AlphaFoldDBP50281
Gene CardMMP14
Uniprot IDP50281
PfamPF11857; PF00045; PF00413; PF01471
In ASDno
Allosteric Predictionyes (0.466228021)
Ortholog in AnimalsAlpaca_ MMP14 ( ortholog_one2one )
Dog_ MMP14 ( ortholog_one2one )
GuineaPig_ MMP14 ( ortholog_one2one )
Macaque_ MMP14 ( ortholog_one2one )
Mouse_ Mmp14 ( ortholog_one2one )
Pig_ MMP14 ( ortholog_one2one )
Rat_ Mmp14 ( ortholog_one2one )
OhnologsMMP15, MMP24, MMP16
ParalogsMMP24, MMP16, MMP21, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11
TissueNA
Tissue SpecificityExpressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. {ECO:0000269|PubMed:18223680}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1BQQ  (X-ray  2.75A  )  1BUV  (X-ray  2.75A  )  2MQS  (NMR  -  )  3C7X  (X-ray  1.70A  )  3MA2  (X-ray  2.05A  )  3X23  (X-ray  2.40A  )  4P3C  (X-ray  1.94A  )  4P3D  (X-ray  1.95A  )  4QXU  (X-ray  2.30A  )  5H0U  (X-ray  2.24A  )  6CLZ  (NMR  -  )  6CM1  (NMR  -  ) 
DBSNP rs17882219  rs17884647  rs1042703  rs587777039  rs17884841  rs1042704  rs17884719  rs17880989  rs3751489 
Subcellular location [CC]Membrane {ECO:0000305};
Single-pass type I membrane protein {ECO:0000305}. Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.
Mouse PG classificationNA
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