| Gene Information | |
|---|---|
| Gene Name | TRIM22 |
| Organism | Homo sapiens (Human) |
| Gene Length | 498 |
| Protein Names | E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000132274 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q8IYM9 |
| Gene Card | TRIM22 |
| Uniprot ID | Q8IYM9 |
| Pfam | PF00622; PF00643; PF13445 |
| In ASD | no |
| Allosteric Prediction | no (-0.942381657) |
| Ortholog in Animals | Alpaca_ TRIM22 ( ortholog_one2one ) Dog_ TRIM22 ( ortholog_one2one ) Macaque_ TRIM22 ( ortholog_one2one ) Mouse_ Trim75 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRIM42, TRIM13, TRIM31, TRIM49B, TRIM49C, TRIM49, TRIM33, TRIM69, TRIM71, TRIM77, TRIM28, TRIM3, TRIM46, TRIM58, TRIM38, TRIM5, TRIM37, MID1, TRIM7, TRIM36, TRIM44, TRIML2, TRIM2, TRIM63, TRIM73, TRIM74, TRIM65, TRIML1, MID2, TRIM32, TRIM14, TRIM34, TRIM54, TRIM55, TRIM52, TRIM41, TRIM11, PML, TRIM43, TRIM43B, TRIM21, TRIM6, TRIM27, TRIM40, TRIM51G, TRIM51, TRIM9, TRIM67, TRIM25, TRIM49D1, TRIM48, TRIM49D2, TRIM68, TRIM17, TRIM24, TRIM64C, TRIM64, TRIM64B, TRIM60, TRIM61, TRIM4, TRIM10, BSPRY, TRIM56, TRIM29, TRIM8, MEFV, TRIM15, TRIM35, TRIM16, TRIM47, TRIM45, TRIM72, TRIM62, TRIM50, TRIM75, TRIM66, RNF39, TRIM26, TRIM39 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269|PubMed:7797467}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs7935564 rs2291843 rs1063303 rs12364019 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17156811}. Nucleus {ECO:0000269|PubMed:17156811}. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies. |
| Mouse PG classification | NA |
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