| Gene Information | |
|---|---|
| Gene Name | MMP12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 470 |
| Protein Names | Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12) |
| Target Name | macrophage metalloelastase |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000262406 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P39900 |
| Gene Card | MMP12 |
| Uniprot ID | P39900 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | yes (0.26418802) |
| Ortholog in Animals | Alpaca_ MMP12 ( ortholog_one2one ) Dog_ MMP12 ( ortholog_one2one ) GuineaPig_ MMP12 ( ortholog_one2one ) Macaque_ MMP12 ( ortholog_one2one ) Mouse_ Mmp12 ( ortholog_one2one ) Pig_ MMP12 ( ortholog_one2one ) Rat_ Mmp12 ( ortholog_one2one ) Rabbit_ MMP12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MMP24, MMP16, MMP21, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | NA |
| Tissue Specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JIZ (X-ray 2.60A ) 1JK3 (X-ray 1.09A ) 1OS2 (X-ray 2.15A ) 1OS9 (X-ray 1.85A ) 1RMZ (X-ray 1.34A ) 1ROS (X-ray 2.00A ) 1UTT (X-ray 2.20A ) 1UTZ (X-ray 2.50A ) 1Y93 (X-ray 1.03A ) 1YCM (NMR - ) 1Z3J (NMR - ) 2HU6 (X-ray 1.32A ) 2JXY (NMR - ) 2K2G (NMR - ) 2K9C (NMR - ) 2KRJ (NMR - ) 2MLR (NMR - ) 2MLS (NMR - ) 2N8R (NMR - ) 2OXU (X-ray 1.24A ) 2OXW (X-ray 1.15A ) 2OXZ (X-ray 1.90A ) 2POJ (NMR - ) 2W0D (X-ray 2.00A ) 2WO8 (X-ray 2.00A ) 2WO9 (X-ray 1.70A ) 2WOA (X-ray 2.30A ) 2Z2D (NMR - ) 3BA0 (X-ray 3.00A ) 3EHX (X-ray 1.90A ) 3EHY (X-ray 1.90A ) 3F15 (X-ray 1.70A ) 3F16 (X-ray 1.16A ) 3F17 (X-ray 1.10A ) 3F18 (X-ray 1.13A ) 3F19 (X-ray 1.13A ) 3F1A (X-ray 1.25A ) 3LIK (X-ray 1.80A ) 3LIL (X-ray 1.80A ) 3LIR (X-ray 1.90A ) 3LJG (X-ray 1.31A ) 3LK8 (X-ray 1.80A ) 3LKA (X-ray 1.80A ) 3N2U (X-ray 1.81A ) 3N2V (X-ray 1.55A ) 3NX7 (X-ray 1.80A ) 3RTS (X-ray 1.81A ) 3RTT (X-ray 1.82A ) 3TS4 (X-ray 1.59A ) 3TSK (X-ray 2.00A ) 3UVC (X-ray 1.30A ) 4EFS (X-ray 1.63A ) 4GQL (X-ray 1.15A ) 4GR0 (X-ray 1.50A ) 4GR3 (X-ray 1.49A ) 4GR8 (X-ray 1.30A ) 4GUY (X-ray 2.00A ) 4H30 (X-ray 1.43A ) 4H49 (X-ray 2.16A ) 4H76 (X-ray 1.50A ) 4H84 (X-ray 1.59A ) 4I03 (X-ray 1.70A ) 4IJO (X-ray 1.90A ) 5CXA (X-ray 1.30A ) 5CZM (X-ray 1.30A ) 5D2B (X-ray 1.20A ) 5D3C (X-ray 1.31A ) 5I0L (X-ray 2.45A ) 5I2Z (X-ray 2.30A ) 5I3M (X-ray 2.17A ) 5I43 (X-ray 1.95A ) 5I4O (X-ray 2.05A ) 5L79 (X-ray 2.07A ) 5L7F (X-ray 1.80A ) 5LAB (X-ray 1.34A ) 5N5J (X-ray 1.80A ) 5N5K (X-ray 1.80A ) 6EKN (X-ray 1.20A ) 6ELA (X-ray 1.49A ) 6ENM (X-ray 1.59A ) 6EOX (X-ray 1.30A ) 6RD0 (X-ray 1.90A ) 6RLY (X-ray 2.20A ) 7OVY (X-ray 1.24A ) |
| DBSNP | rs652438 rs28381701 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000305}. |
| Mouse PG classification | NA |
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