| Gene Information | |
|---|---|
| Gene Name | MME |
| Organism | Homo sapiens (Human) |
| Gene Length | 750 |
| Protein Names | Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) |
| Target Name | neutral endopeptidase |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000196549 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P08473 |
| Gene Card | MME |
| Uniprot ID | P08473 |
| Pfam | PF01431; PF05649 |
| In ASD | no |
| Allosteric Prediction | yes (0.869291557) |
| Ortholog in Animals | Alpaca_ MME ( ortholog_one2one ) Dog_ MME ( ortholog_one2one ) GuineaPig_ MME ( ortholog_one2one ) Macaque_ MME ( ortholog_one2one ) Mouse_ Mme ( ortholog_one2one ) Pig_ MME ( ortholog_one2one ) Rat_ Mme ( ortholog_one2one ) Rabbit_ MME ( ortholog_one2one ) |
| Ohnologs | ECE1, MMEL1, ECEL1 |
| Paralogs | KEL, MMEL1, PHEX, ECE1, ECE2, ECEL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DMT (X-ray 2.10A ) 1R1H (X-ray 1.95A ) 1R1I (X-ray 2.60A ) 1R1J (X-ray 2.35A ) 1Y8J (X-ray 2.25A ) 2QPJ (X-ray 2.05A ) 2YB9 (X-ray 2.40A ) 4CTH (X-ray 2.15A ) 5JMY (X-ray 2.00A ) 6GID (X-ray 1.90A ) 6SH1 (X-ray 2.10A ) 6SH2 (X-ray 2.60A ) 6SUK (X-ray 1.75A ) 6SVY (X-ray 2.60A ) 6THP (X-ray 2.54A ) 6XVP (X-ray 2.65A ) |
| DBSNP | rs879255651 rs138218277 rs199567914 rs777476150 rs200308207 rs879253752 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20876573}; Single-pass type II membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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