| Gene Information | |
|---|---|
| Gene Name | L2HGDH |
| Organism | Homo sapiens (Human) |
| Gene Length | 463 |
| Protein Names | L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) (Duranin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000087299 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9H9P8 |
| Gene Card | L2HGDH |
| Uniprot ID | Q9H9P8 |
| Pfam | PF01266 |
| In ASD | no |
| Allosteric Prediction | no (-0.169317039) |
| Ortholog in Animals | Alpaca_ L2HGDH ( ortholog_one2one ) Dog_ L2HGDH ( ortholog_one2one ) GuineaPig_ L2HGDH ( ortholog_one2one ) Macaque_ L2HGDH ( ortholog_one2one ) Mouse_ L2hgdh ( ortholog_one2one ) Pig_ L2HGDH ( ortholog_one2one ) Rat_ L2hgdh ( ortholog_one2one ) Rabbit_ L2HGDH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | YPEL3, YPEL2, DMGDH, AMT, YPEL4, PDPR, SARDH, FOXRED1, YPEL1, YPEL5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow. {ECO:0000269|PubMed:15385440}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2275591 rs35710558 rs118204021 rs199690954 rs970541687 rs267607206 rs770542189 rs118204020 rs750044734 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:16005139}. |
| Mouse PG classification | NA |
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