| Gene Information | |
|---|---|
| Gene Name | MLYCD |
| Organism | Homo sapiens (Human) |
| Gene Length | 493 |
| Protein Names | Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000103150 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O95822 |
| Gene Card | MLYCD |
| Uniprot ID | O95822 |
| Pfam | PF05292; PF17408 |
| In ASD | no |
| Allosteric Prediction | yes (0.430493314) |
| Ortholog in Animals | Alpaca_ MLYCD ( ortholog_one2one ) Dog_ MLYCD ( ortholog_one2one ) GuineaPig_ MLYCD ( ortholog_one2one ) Mouse_ Mlycd ( ortholog_one2one ) Pig_ MLYCD ( ortholog_one2one ) Rat_ Mlycd ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. {ECO:0000269|PubMed:10455107, ECO:0000269|PubMed:18314420}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2YGW (X-ray 2.80A ) 4F0X (X-ray 3.29A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10417274}. Mitochondrion matrix {ECO:0000269|PubMed:10417274}. Peroxisome {ECO:0000269|PubMed:10417274}. Peroxisome matrix {ECO:0000250|UniProtKB:Q920F5}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250|UniProtKB:Q920F5}. |
| Mouse PG classification | NA |
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