| Gene Information | |
|---|---|
| Gene Name | MLXIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000175727 ) 3 ( ENSG00000281178 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9HAP2 |
| Gene Card | MLXIP |
| Uniprot ID | Q9HAP2 |
| Pfam | PF00010 |
| In ASD | no |
| Allosteric Prediction | no (-0.143441254) |
| Ortholog in Animals | Alpaca_ MLXIP ( ortholog_one2one ) Dog_ MLXIP ( ortholog_one2one ) GuineaPig_ MLXIP ( ortholog_one2one ) Macaque_ MLXIP ( ortholog_one2one ) Mouse_ Mlxip ( ortholog_one2one ) Pig_ MLXIP ( ortholog_one2one ) Rat_ Mlxip ( ortholog_one2one ) Rabbit_ MLXIP ( ortholog_one2one ) |
| Ohnologs | MLXIPL |
| Paralogs | MLX, MLXIPL, TFAP4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed in adult tissues. Most abundant in skeletal muscle. {ECO:0000269|PubMed:11073985}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs7978353 rs34702867 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Mitochondrion outer membrane {ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q2VPU4, ECO:0000269|PubMed:12446771, ECO:0000269|PubMed:16782875}. |
| Mouse PG classification | NA |
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