| Gene Information | |
|---|---|
| Gene Name | MLT |
| Organism | Homo sapiens (Human) |
| Gene Length | 824 |
| Protein Names | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UDY8 |
| Gene Card | MALT1 |
| Uniprot ID | Q9UDY8 |
| Pfam | PF13895; PF18703 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2G7R (X-ray 2.70A ) 3BFO (X-ray 1.15A ) 3K0W (X-ray 2.80A ) 3UO8 (X-ray 1.90A ) 3UOA (X-ray 1.75A ) 3V4O (X-ray 2.10A ) 3V55 (X-ray 1.81A ) 4I1P (X-ray 2.40A ) 4I1R (X-ray 2.70A ) 6F7I (X-ray 2.43A ) 6GK2 (EM 4.90A ) 6H4A (X-ray 2.65A ) 6YN8 (X-ray 3.05A ) 6YN9 (X-ray 2.56A ) 7A41 (X-ray 2.13A ) 7AK0 (X-ray 2.32A ) 7AK1 (X-ray 2.51A ) 7PAV (X-ray 2.20A ) 7PAW (X-ray 2.19A ) 8CZO (EM 4.30A ) |
| DBSNP | rs398123058 rs35533328 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000269|PubMed:16123224}. Nucleus {ECO:0000269|PubMed:16123224}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. {ECO:0000269|PubMed:16123224}. |
| Mouse PG classification | NA |
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