| Gene Information | |
|---|---|
| Gene Name | PIGR |
| Organism | Homo sapiens (Human) |
| Gene Length | 764 |
| Protein Names | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000162896 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01833 |
| Gene Card | PIGR |
| Uniprot ID | P01833 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.080683672) |
| Ortholog in Animals | Alpaca_ PIGR ( ortholog_one2one ) Dog_ PIGR ( ortholog_one2one ) GuineaPig_ PIGR ( ortholog_one2one ) Macaque_ PIGR ( ortholog_one2one ) Mouse_ Pigr ( ortholog_one2one ) Pig_ PIGR ( ortholog_one2one ) Rat_ Pigr ( ortholog_one2one ) Rabbit_ PIGR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TREML1, FCAMR, CD300LD, TMIGD3, CD300H, CD300LF, CD300C, CD300LG, CD300A, FCMR, CD300E, TREM2, CD300LB |
| Tissue | parotid.gland, submandibular.gland, minor.salivary.gland, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1XED (X-ray 1.90A ) 2OCW (X-ray - ) 3CHN (Other 1.00A ) 3CM9 (Other 1.00A ) 5D4K (X-ray 2.60A ) 6KXS (EM 3.40A ) 6LX3 (EM 3.15A ) 6LXW (EM 3.27A ) 6UE7 (EM 2.90A ) 6UE8 (EM 3.00A ) 6UE9 (EM 2.90A ) 6UEA (EM 3.00A ) 7K0C (EM 3.30A ) |
| DBSNP | rs2275531 rs7542760 rs291102 |
| Subcellular location [CC] | [Polymeric immunoglobulin receptor]: Cell membrane {ECO:0000269|PubMed:9379029}; Single-pass type I membrane protein {ECO:0000255}.; [Secretory component]: Secreted {ECO:0000269|PubMed:16543244, ECO:0000269|PubMed:19079336, ECO:0000269|PubMed:8292260}. |
| Mouse PG classification | NA |
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