| Gene Information | |
|---|---|
| Gene Name | MCM8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 840 |
| Protein Names | DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1934 ( ENSG00000125885 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9UJA3 |
| Gene Card | MCM8 |
| Uniprot ID | Q9UJA3 |
| Pfam | PF00493; PF17855; PF17207 |
| In ASD | no |
| Allosteric Prediction | no (-0.069083004) |
| Ortholog in Animals | Alpaca_ MCM8 ( ortholog_one2one ) Dog_ MCM8 ( ortholog_one2one ) GuineaPig_ MCM8 ( ortholog_one2one ) Macaque_ MCM8 ( ortholog_one2one ) Mouse_ Mcm8 ( ortholog_one2one ) Pig_ MCM8 ( ortholog_one2one ) Rat_ Mcm8 ( ortholog_one2one ) Rabbit_ MCM8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MCMDC2, MCM4, MCM9, MCM2, MCM5, MCM6, MCM7, MCM3 |
| Tissue | NA |
| Tissue Specificity | Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers. {ECO:0000269|PubMed:12771218}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.170291(Rat);0.155475(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6L0O (X-ray 1.21A ) 7DP3 (X-ray 2.55A ) |
| DBSNP | rs236110 rs6117014 rs606231343 rs16991591 rs16991615 rs28403619 rs16991638 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12527764, ECO:0000269|PubMed:18072282, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}. Chromosome {ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. Note=Localizes to nuclear foci (PubMed:26215093). Localizes to double-stranded DNA breaks (PubMed:23401855). Binds chromatin throughout the cell cycle (PubMed:15684404). {ECO:0000269|PubMed:15684404, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093}. |
| Mouse PG classification | HPG |
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