| Gene Information | |
|---|---|
| Gene Name | CDH11 |
| Organism | Homo sapiens (Human) |
| Gene Length | 796 |
| Protein Names | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) |
| Target Name | osteoblast cadherin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000140937 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P55287 |
| Gene Card | CDH11 |
| Uniprot ID | P55287 |
| Pfam | PF01049; PF00028 |
| In ASD | no |
| Allosteric Prediction | no (-0.133254726) |
| Ortholog in Animals | Alpaca_ CDH11 ( ortholog_one2one ) Dog_ CDH11 ( ortholog_one2one ) Macaque_ CDH11 ( ortholog_one2one ) Mouse_ Cdh11 ( ortholog_one2one ) Pig_ CDH11 ( ortholog_one2one ) Rat_ Cdh11 ( ortholog_one2one ) Rabbit_ CDH11 ( ortholog_one2one ) |
| Ohnologs | CDH19, CDH7, CDH20, CDH13, CDH22, CDH2, CDH4, CDH10, CDH9, CDH6, CDH15, CDH24, CDH18, CDH12 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH10, CDH12, CDH13, CDH6, CDH1, CDHR2, CDH22, CDH5, CDH2, CDH8 |
| Tissue | NA |
| Tissue Specificity | Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546). {ECO:0000269|PubMed:33811546}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35195 rs1426094439 rs1130821 rs35213 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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