| Gene Information | |
|---|---|
| Gene Name | TICAM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 712 |
| Protein Names | TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000127666 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IUC6 |
| Gene Card | TICAM1 |
| Uniprot ID | Q8IUC6 |
| Pfam | PF12721; PF17798 |
| In ASD | no |
| Allosteric Prediction | yes (0.03660874) |
| Ortholog in Animals | Alpaca_ TICAM1 ( ortholog_one2one ) GuineaPig_ TICAM1 ( ortholog_one2one ) Macaque_ TICAM1 ( ortholog_one2one ) Mouse_ Ticam1 ( ortholog_one2one ) Pig_ TICAM1 ( ortholog_one2one ) Rat_ AABR07066529.1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed but with higher levels in liver. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2M1X (NMR - ) 2M63 (NMR - ) 3RC4 (X-ray 1.50A ) 4BSX (X-ray 2.23A ) 4C0M (X-ray 2.80A ) 5JEL (X-ray 1.60A ) |
| DBSNP | rs114566317 rs201782115 rs372818181 rs11466719 rs199816697 rs201291933 rs770166865 rs146550489 rs11466721 rs147816959 rs143066432 rs561021962 rs150224968 rs11466724 |
| Subcellular location [CC] | Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21695056}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80UF7}. Mitochondrion {ECO:0000250|UniProtKB:Q80UF7}. Note=Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:21695056}. |
| Mouse PG classification | NA |
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