| Gene Information | |
|---|---|
| Gene Name | MLCK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1914 |
| Protein Names | Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q15746 |
| Gene Card | MYLK |
| Uniprot ID | Q15746 |
| Pfam | PF00041; PF07679; PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Smooth muscle and non-muscle isozymes are expressed in a wide variety of adult and fetal tissues and in cultured endothelium with qualitative expression appearing to be neither tissue- nor development-specific. Non-muscle isoform 2 is the dominant splice variant expressed in various tissues. Telokin has been found in a wide variety of adult and fetal tissues. Accumulates in well differentiated enterocytes of the intestinal epithelium in response to tumor necrosis factor (TNF). {ECO:0000269|PubMed:10536370, ECO:0000269|PubMed:16835238, ECO:0000269|PubMed:20053363, ECO:0000269|PubMed:8575746}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003490(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2CQV (NMR - ) 2K0F (NMR - ) 2YR3 (NMR - ) 5JQA (X-ray 1.80A ) 5JTH (X-ray 1.84A ) 6C6M (X-ray 2.50A ) |
| DBSNP | rs28497577 rs143896146 rs140148380 rs111256888 rs3796164 rs55846245 rs35912339 rs56378658 rs35436690 rs35156360 rs750686734 rs138172035 rs776858093 rs142835596 rs112537316 rs3732485 rs3732486 rs34542174 rs3732487 rs75370906 rs368390254 rs181663420 rs1576422965 rs34982967 rs1576401641 rs387906781 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:20053363}. Cell projection, lamellipodium {ECO:0000269|PubMed:20053363}. Cleavage furrow {ECO:0000269|PubMed:15020676}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:15020676}. Note=Localized to stress fibers during interphase and to the cleavage furrow during mitosis. {ECO:0000269|PubMed:15020676}. |
| Mouse PG classification | NA |
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