| Gene Information | |
|---|---|
| Gene Name | CXCL12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 93 |
| Protein Names | Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)] |
| Target Name | stromal cell-derived factor 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000107562 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48061 |
| Gene Card | CXCL12 |
| Uniprot ID | P48061 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.535773405) |
| Ortholog in Animals | Alpaca_ CXCL12 ( ortholog_one2one ) Dog_ CXCL12 ( ortholog_one2one ) GuineaPig_ CXCL12 ( ortholog_one2one ) Macaque_ CXCL12 ( ortholog_one2one ) Mouse_ Cxcl12 ( ortholog_one2one ) Pig_ CXCL12 ( ortholog_one2one ) Rat_ Cxcl12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. {ECO:0000269|PubMed:16626895}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A15 (X-ray 2.20A ) 1QG7 (X-ray 2.00A ) 1SDF (NMR - ) 1VMC (NMR - ) 2J7Z (X-ray 1.95A ) 2K01 (NMR - ) 2K03 (NMR - ) 2K04 (NMR - ) 2K05 (NMR - ) 2KEC (NMR - ) 2KED (NMR - ) 2KEE (NMR - ) 2KOL (NMR - ) 2N55 (NMR - ) 2NWG (X-ray 2.07A ) 2SDF (NMR - ) 3GV3 (X-ray 1.60A ) 3HP3 (X-ray 2.20A ) 4LMQ (X-ray 2.77A ) 4UAI (X-ray 1.90A ) 6SHR (X-ray 1.75A ) 7SK3 (EM 3.80A ) 7SK4 (EM 3.30A ) 7SK5 (EM 4.00A ) 7SK6 (EM 4.00A ) 7SK7 (EM 3.30A ) 7SK8 (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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