| Gene Information | |
|---|---|
| Gene Name | MLANA |
| Organism | Homo sapiens (Human) |
| Gene Length | 118 |
| Protein Names | Melanoma antigen recognized by T-cells 1 (MART-1) (Antigen LB39-AA) (Antigen SK29-AA) (Protein Melan-A) |
| Target Name | mart-1 melanoma antigen |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000120215 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q16655 |
| Gene Card | MLANA |
| Uniprot ID | Q16655 |
| Pfam | PF14991 |
| In ASD | no |
| Allosteric Prediction | no (-0.964731031) |
| Ortholog in Animals | Alpaca_ MLANA ( ortholog_one2one ) Dog_ MLANA ( ortholog_one2one ) GuineaPig_ MLANA ( ortholog_one2one ) Macaque_ MLANA ( ortholog_one2one ) Mouse_ Mlana ( ortholog_one2one ) Pig_ MLANA ( ortholog_one2one ) Rat_ Mlana ( ortholog_one2one ) Rabbit_ MLANA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | skin |
| Tissue Specificity | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GT9 (X-ray 1.75A ) 2GTW (X-ray 1.55A ) 2GTZ (X-ray 1.70A ) 2GUO (X-ray 1.90A ) 3HG1 (X-ray 3.00A ) 3L6F (X-ray 2.10A ) 3MRO (X-ray 2.35A ) 3MRP (X-ray 2.10A ) 3MRQ (X-ray 2.20A ) 3QDM (X-ray 2.80A ) 3QEQ (X-ray 2.59A ) 3QFD (X-ray 1.68A ) 4EUP (X-ray 2.88A ) 4JFF (X-ray 2.43A ) 4L3E (X-ray 2.56A ) 4QOK (X-ray 3.00A ) 4WJ5 (X-ray 1.65A ) 5E9D (X-ray 2.51A ) 5NHT (X-ray 3.20A ) 5NQK (X-ray 3.25A ) 6D78 (X-ray 2.35A ) 6DKP (X-ray 2.97A ) 6TMO (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation. |
| Mouse PG classification | NA |
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