| Gene Information | |
|---|---|
| Gene Name | SFRP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Secreted frizzled-related protein 5 (sFRP-5) (Frizzled-related protein 1b) (FRP-1b) (Secreted apoptosis-related protein 3) (SARP-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000120057 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5T4F7 |
| Gene Card | SFRP5 |
| Uniprot ID | Q5T4F7 |
| Pfam | PF01392; PF01759 |
| In ASD | no |
| Allosteric Prediction | no (-0.920724912) |
| Ortholog in Animals | Alpaca_ SFRP5 ( ortholog_one2one ) Dog_ SFRP5 ( ortholog_one2one ) GuineaPig_ SFRP5 ( ortholog_one2one ) Macaque_ SFRP5 ( ortholog_one2one ) Mouse_ Sfrp5 ( ortholog_one2one ) Pig_ SFRP5 ( ortholog_one2one ) Rat_ Sfrp5 ( ortholog_one2one ) Rabbit_ SFRP5 ( ortholog_one2one ) |
| Ohnologs | SFRP1, SFRP2 |
| Paralogs | SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD4, FZD3 |
| Tissue | duodenum, pancreas, small.intestine, gall.bladder, tibial.nerve |
| Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. {ECO:0000269|PubMed:10072424, ECO:0000269|PubMed:9391078, ECO:0000269|PubMed:9642118}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11815012 |
| Subcellular location [CC] | Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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