| Gene Information | |
|---|---|
| Gene Name | MKP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P28562 |
| Gene Card | DUSP1 |
| Uniprot ID | P28562 |
| Pfam | PF00782; PF00581 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. {ECO:0000269|PubMed:8106404}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6APX (X-ray 2.49A ) 6D65 (X-ray 2.35A ) 6D66 (X-ray 2.23A ) 6D67 (X-ray 2.55A ) |
| DBSNP | rs34013988 rs34471628 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q91790}. |
| Mouse PG classification | NA |
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