Gene Information
Gene NameMKNK2
OrganismHomo sapiens (Human)
Gene Length465
Protein NamesMAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
Target Namemap kinase signal-integrating kinase 2
Target TypeClinical trial target
Gene Age987 ( ENSG00000099875 )
Evolutionary StageEukaryota
AlphaFoldDBQ9HBH9
Gene CardMKNK2
Uniprot IDQ9HBH9
PfamPF00069
In ASDno
Allosteric Predictionno (-0.135912662)
Ortholog in AnimalsAlpaca_ MKNK2 ( ortholog_one2one )
Dog_ MKNK2 ( ortholog_one2one )
GuineaPig_ MKNK2 ( ortholog_one2one )
Macaque_ MKNK2 ( ortholog_one2one )
Mouse_ Mknk2 ( ortholog_one2one )
Pig_ MKNK2 ( ortholog_one2one )
Rat_ Mknk2 ( ortholog_one2one )
OhnologsMKNK1
ParalogsMAPKAPK3, MAPKAPK5, MKNK1, MAPKAPK2, CAMK4, DCX
TissueNA
Tissue SpecificityUbiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. {ECO:0000269|PubMed:11013076}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2AC3  (X-ray  2.10A  )  2AC5  (X-ray  3.20A  )  2HW7  (X-ray  2.71A  )  6CJ5  (X-ray  2.80A  )  6CJE  (X-ray  3.36A  )  6CJH  (X-ray  3.60A  )  6CJW  (X-ray  3.38A  )  6CJY  (X-ray  3.05A  )  6CK3  (X-ray  2.90A  )  6CK6  (X-ray  3.32A  )  6CKI  (X-ray  2.95A  )  6JLR  (X-ray  2.90A  ) 
DBSNP rs3746101  rs56158214  rs34475638 
Subcellular location [CC][Isoform 2]: Nucleus, PML body.;
[Isoform 1]: Cytoplasm.
Mouse PG classificationNA
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