| Gene Information | |
|---|---|
| Gene Name | CERK |
| Organism | Homo sapiens (Human) |
| Gene Length | 537 |
| Protein Names | Ceramide kinase (hCERK) (EC 2.7.1.138) (Acylsphingosine kinase) (Lipid kinase 4) (LK4) |
| Target Name | ceramide kinase |
| Target Type | Literature-reported target |
| Gene Age | 680 ( ENSG00000100422 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCT0 |
| Gene Card | CERK |
| Uniprot ID | Q8TCT0 |
| Pfam | PF19280; PF00781 |
| In ASD | no |
| Allosteric Prediction | no (-0.390224055) |
| Ortholog in Animals | Alpaca_ CERK ( ortholog_one2one ) Dog_ CERK ( ortholog_one2one ) GuineaPig_ CERK ( ortholog_one2one ) Macaque_ CERK ( ortholog_one2one ) Mouse_ Cerk ( ortholog_one2one ) Pig_ CERK ( ortholog_one2one ) Rat_ Cerk ( ortholog_one2one ) Rabbit_ CERK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPHK1, SPHK2, CERKL, AGK |
| Tissue | NA |
| Tissue Specificity | High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung. {ECO:0000269|PubMed:11956206}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16995615 rs9306515 rs13057352 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19168031}. Cell membrane {ECO:0000269|PubMed:16269826, ECO:0000269|PubMed:19168031}; Peripheral membrane protein {ECO:0000269|PubMed:19168031}. |
| Mouse PG classification | NA |
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