| Gene Information | |
|---|---|
| Gene Name | MISP |
| Organism | Homo sapiens (Human) |
| Gene Length | 679 |
| Protein Names | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000099812 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8IVT2 |
| Gene Card | MISP |
| Uniprot ID | Q8IVT2 |
| Pfam | PF15304 |
| In ASD | no |
| Allosteric Prediction | no (-1.580507232) |
| Ortholog in Animals | Alpaca_ MISP ( ortholog_one2one ) Dog_ MISP ( ortholog_one2one ) Macaque_ MISP ( ortholog_one2one ) Mouse_ Misp ( ortholog_one2one ) Pig_ MISP ( ortholog_one2one ) Rat_ Misp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MISP3 |
| Tissue | colon, gall.bladder, small.intestine, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs45477999 rs3746173 rs3746175 rs35384259 rs8107847 |
| Subcellular location [CC] | Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis. |
| Mouse PG classification | NA |
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