| Gene Information | |
|---|---|
| Gene Name | MAPKKK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y2U5 |
| Gene Card | MAP3K2 |
| Uniprot ID | Q9Y2U5 |
| Pfam | PF00564; PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001375(Rat);0.007407(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CU1 (NMR - ) 2NPT (X-ray 1.75A ) 5EX0 (X-ray 2.70A ) 5HQ8 (X-ray 1.72A ) 6LDV (X-ray 1.90A ) 6LDW (X-ray 1.60A ) 6LDX (X-ray 1.80A ) 6LDY (X-ray 1.77A ) |
| DBSNP | rs55767983 rs56307783 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15075238}. Nucleus {ECO:0000269|PubMed:15075238}. Note=Upon EGF stimulation, translocates into the nucleus. |
| Mouse PG classification | NA |
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