| Gene Information | |
|---|---|
| Gene Name | MIRK |
| Organism | Homo sapiens (Human) |
| Gene Length | 629 |
| Protein Names | Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y463 |
| Gene Card | DYRK1B |
| Uniprot ID | Q9Y463 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. {ECO:0000269|PubMed:10910078}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34587974 rs587777380 rs367643250 rs55687541 rs35858874 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:32611815, ECO:0000269|PubMed:33469661}. Nucleus, nucleolus {ECO:0000269|PubMed:33469661}. Chromosome {ECO:0000269|PubMed:32611815}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. {ECO:0000269|PubMed:32611815}. |
| Mouse PG classification | NA |
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