| Gene Information | |
|---|---|
| Gene Name | KIRREL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000183853 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96J84 |
| Gene Card | KIRREL1 |
| Uniprot ID | Q96J84 |
| Pfam | PF08205; PF07679 |
| In ASD | no |
| Allosteric Prediction | yes (0.096148118) |
| Ortholog in Animals | Alpaca_ KIRREL1 ( ortholog_one2one ) Dog_ KIRREL1 ( ortholog_one2one ) GuineaPig_ KIRREL1 ( ortholog_one2one ) Macaque_ KIRREL1 ( ortholog_one2one ) Mouse_ Kirrel ( ortholog_one2one ) Pig_ KIRREL1 ( ortholog_one2one ) Rat_ Kirrel1 ( ortholog_one2one ) Rabbit_ KIRREL1 ( ortholog_one2one ) |
| Ohnologs | KIRREL2, KIRREL3 |
| Paralogs | KIRREL2, KIRREL3, NPHS1 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269|PubMed:11416156}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35927201 rs764090370 rs139995772 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:31472902}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. |
| Mouse PG classification | NA |
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