| Gene Information | |
|---|---|
| Gene Name | DLG5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1919 |
| Protein Names | Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151208 ) 3 ( ENSG00000274429 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TDM6 |
| Gene Card | DLG5 |
| Uniprot ID | Q8TDM6 |
| Pfam | PF00625; PF00595; PF04822 |
| In ASD | no |
| Allosteric Prediction | no (-0.606792262) |
| Ortholog in Animals | Alpaca_ DLG5 ( ortholog_one2one ) Dog_ DLG5 ( ortholog_one2one ) GuineaPig_ DLG5 ( ortholog_one2one ) Macaque_ DLG5 ( ortholog_one2one ) Mouse_ Dlg5 ( ortholog_one2one ) Pig_ DLG5 ( ortholog_one2one ) Rat_ Dlg5 ( ortholog_one2one ) Rabbit_ DLG5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TJP2, TJP3, TJP1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level) (PubMed:28169360). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain. {ECO:0000269|PubMed:11876824, ECO:0000269|PubMed:12657639, ECO:0000269|PubMed:28169360, ECO:0000269|PubMed:9738934}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1UIT (NMR - ) |
| DBSNP | rs1248696 rs2289310 rs4979794 |
| Subcellular location [CC] | Cell junction {ECO:0000269|PubMed:12657639, ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:12657639}; Peripheral membrane protein {ECO:0000269|PubMed:12657639}. Postsynaptic density {ECO:0000250|UniProtKB:E9Q9R9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:E9Q9R9}. Note=Localized at sites of cell-cell contact. |
| Mouse PG classification | NA |
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