Gene Information
Gene NameMINK1
OrganismHomo sapiens (Human)
Gene Length1332
Protein NamesMisshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Target Namemisshapen-like kinase 1
Target TypeNA
Gene Age1714 ( ENSG00000141503 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ8N4C8
Gene CardMINK1
Uniprot IDQ8N4C8
PfamPF00780; PF00069
In ASDno
Allosteric Predictionyes (0.185114199)
Ortholog in AnimalsAlpaca_ MINK1 ( ortholog_one2one )
Dog_ MINK1 ( ortholog_one2one )
GuineaPig_ MINK1 ( ortholog_one2one )
Macaque_ MINK1 ( ortholog_one2one )
Mouse_ Mink1 ( ortholog_one2one )
Pig_ MINK1 ( ortholog_one2one )
Rat_ Mink1 ( ortholog_one2one )
Rabbit_ MINK1 ( ortholog_one2one )
OhnologsMAP4K4, TNIK
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, TNIK
TissueNA
Tissue SpecificityExpressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis. {ECO:0000269|PubMed:15469942}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs56131206  rs11556634  rs11556635  rs2302319 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15469942, ECO:0000269|PubMed:18930710}. Postsynaptic density {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.;
[Isoform 4]: Golgi apparatus.
Mouse PG classificationNA
click here to return to the previous page