| Gene Information | |
|---|---|
| Gene Name | HPP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 374 |
| Protein Names | Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UIK5 |
| Gene Card | TMEFF2 |
| Uniprot ID | Q9UIK5 |
| Pfam | PF07648 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. {ECO:0000269|PubMed:10903839, ECO:0000269|PubMed:10987305, ECO:0000269|PubMed:11120884, ECO:0000269|PubMed:11668495, ECO:0000269|PubMed:16439095, ECO:0000269|PubMed:16805794}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 2]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; [Isoform 3]: Secreted. |
| Mouse PG classification | NA |
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