| Gene Information | |
|---|---|
| Gene Name | CTNNA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000044115 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P35221 |
| Gene Card | CTNNA1 |
| Uniprot ID | P35221 |
| Pfam | PF01044 |
| In ASD | no |
| Allosteric Prediction | yes (0.502956335) |
| Ortholog in Animals | Alpaca_ CTNNA1 ( ortholog_one2one ) Dog_ CTNNA1 ( ortholog_one2one ) GuineaPig_ CTNNA1 ( ortholog_one2one ) Macaque_ CTNNA1 ( ortholog_one2one ) Mouse_ Ctnna1 ( ortholog_one2one ) Pig_ CTNNA1 ( ortholog_one2one ) Rat_ Ctnna1 ( ortholog_one2one ) Rabbit_ CTNNA1 ( ortholog_one2one ) |
| Ohnologs | CTNNA3, CTNNA2 |
| Paralogs | CTNNA3, CTNNA2, VCL, CTNNAL1 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously in normal tissues. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.012719(Mouse);0.253386(Rat);0.135745(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H6G (X-ray 2.20A ) 4EHP (X-ray 2.66A ) 4IGG (X-ray 3.66A ) 6UPV (EM 3.20A ) 6V2O (X-ray 1.27A ) 6V2P (X-ray 1.30A ) |
| DBSNP | rs781520852 rs28363394 rs28363406 rs869320697 rs869320696 rs755215402 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.; [Isoform 3]: Cell membrane {ECO:0000269|PubMed:21708131}; Peripheral membrane protein {ECO:0000269|PubMed:21708131}; Cytoplasmic side {ECO:0000269|PubMed:21708131}. |
| Mouse PG classification | NA |
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