Gene Information
Gene NamePLA2G15
OrganismHomo sapiens (Human)
Gene Length412
Protein NamesPhospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000103066 )
Evolutionary StageEukaryota
AlphaFoldDBQ8NCC3
Gene CardPLA2G15
Uniprot IDQ8NCC3
PfamPF02450
In ASDno
Allosteric Predictionno (-0.101844886)
Ortholog in AnimalsAlpaca_ PLA2G15 ( ortholog_one2one )
Dog_ PLA2G15 ( ortholog_one2one )
GuineaPig_ PLA2G15 ( ortholog_one2one )
Macaque_ PLA2G15 ( ortholog_one2one )
Mouse_ Pla2g15 ( ortholog_one2one )
Pig_ PLA2G15 ( ortholog_one2one )
Rat_ Pla2g15 ( ortholog_one2one )
Rabbit_ PLA2G15 ( ortholog_one2one )
OhnologsNA
ParalogsLCAT
TissueNA
Tissue SpecificityDetected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508). {ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:20410020}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.08(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4X90  (X-ray  1.84A  )  4X91  (X-ray  2.30A  )  4X92  (X-ray  3.00A  )  4X93  (X-ray  2.60A  )  4X94  (X-ray  2.70A  )  4X95  (X-ray  3.08A  )  4X97  (X-ray  2.65A  )  6MTW  (X-ray  2.00A  ) 
DBSNP NA 
Subcellular location [CC]Lysosome {ECO:0000269|PubMed:23958596}. Secreted {ECO:0000269|PubMed:10092508, ECO:0000269|PubMed:20410020}. Membrane {ECO:0000269|PubMed:25727495};
Peripheral membrane protein {ECO:0000269|PubMed:25727495}.
Mouse PG classificationNA
click here to return to the previous page