Gene Information
Gene NameXBP1
OrganismHomo sapiens (Human)
Gene Length261
Protein NamesX-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000100219 )
Evolutionary StageEumetazoa
AlphaFoldDBP17861
Gene CardXBP1
Uniprot IDP17861
PfamPF07716
In ASDno
Allosteric Predictionno (-0.155596303)
Ortholog in AnimalsAlpaca_ XBP1 ( ortholog_one2one )
Dog_ XBP1 ( ortholog_one2one )
Macaque_ XBP1 ( ortholog_one2one )
Mouse_ Xbp1 ( ortholog_one2one )
Pig_ XBP1 ( ortholog_one2one )
Rat_ Xbp1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
Tissuepancreas
Tissue SpecificityExpressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). {ECO:0000269|PubMed:11460154, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:25280941}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6R5Q  (EM  3.00A  )  6R6G  (EM  3.70A  )  6R6P  (EM  3.10A  )  6R7Q  (EM  3.90A  ) 
DBSNP rs1379560430 
Subcellular location [CC]Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000269|PubMed:23529610}.;
[Isoform 1]: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296}. Cytoplasm {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:25190803}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25239945};
Single-pass type II membrane protein {ECO:0000269|PubMed:25239945}. Endoplasmic reticulum membrane {ECO:0000303|PubMed:25239945};
Peripheral membrane protein {ECO:0000303|PubMed:25239945}. Membrane {ECO:0000269|PubMed:19394296};
Peripheral membrane protein {ECO:0000303|PubMed:19394296}. Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein;
whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:25190803}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.;
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm {ECO:0000269|PubMed:25239945}. Nucleus {ECO:0000269|PubMed:25239945}. Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945). {ECO:0000269|PubMed:25239945}.
Mouse PG classificationNA
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